With the news yesterday that “mini organs” have been grown for the first time using human stem cells, this futuristic area of bio-medicine is clearly accelerating by leaps and bounds. However, harvesting stem cells is a controversial process, since a major method involves harvesting during pregnancy. Now a Swedish startup has raised VC investment to take a new process for generating stem cells — from adult volunteer-donated bone marrow — hailed as a revolutionary tool to alleviate and prevent a wide variety of medical conditions, to industrial-scale levels.
In an exclusive to TechCrunch, Stockholm-based Cellcolabs revealed it has now raised $8.7 million, taking the total amount it has raised to $21.5 million since its founding in 2021.
To date, most stem cells are harvested from adult stem cells or post-termination foetal tissue. The news yesterday detailed how researchers at UCL and Great Ormond Street Hospital in London extracted stem cells that had passed into the amniotic fluid, which surrounds the child in the womb and protects it during pregnancy.
But, for obvious reasons, regulations restrict when these foetal samples can be obtained. In countries like the U.S., foetal sampling is, in fact, completely illegal.
The clinical-stage biotechnology startup raised the round from a number of investors, including Swedish investors Fredrik Österberg and Jens von Bahr (Österberg co-founded Evolution AB with Von Bahr in 2006, which sells casino solutions to online operators). Previous investors include Norrsken Launcher, and the founders of Avito, Jonas Nordlander and Filip Engelbert. The funding will be used to scale up R&D, operations and business development.
Cellcolabs originated from the pioneering stem cell research of Professor Katarina Le Blanc at the world-renowned Karolinska Institute in Stockholm, most famous for inventing the pacemaker, mitochondrial medicine, and winning several Nobel prizes.
Founders Per Båtelson and Maria Rankka, and impact investor Norrsken, joined with Professor Le Blanc to create Cellcolabs, and brought in medically-trained Mattias Bernow as CEO.
Cellcolabs will specialize in Mesenchymal stem cells (MSCs), which are scarce and expensive. According to a statement by the company, these are a type of stem cell with anti-inflammatory, regenerative and immunomodulatory properties, which can “promote the healing of damaged tissue and regulate immune responses to reduce inflammation – an underlying cause of many diseases.” MSCs are also used in the realm of longevity, since inflammation contributes to ageing.
Cellcolabs claims that its process of harvesting the cells from the bone marrow of healthy volunteer donors could slash the price of MSCs by up to 90% within the next decade through large-scale production.
In an interview with TechCrunch, Bernow said, “The promise of stem cells or what it holds, is really mind boggling. For me as a physician, what is really interesting is, of course, if we can use cells to prevent disease. In many cases, I think we will be able to alleviate some of the disease burden.”
“We are really about making the cells available. MSCs are extremely expensive, and they’re very hard to come by. We’ve been granted the opportunity to work with one of the world’s most well-known professors in this area, and to some extent, it’s an unfair advantage and a blessing.”
Bernow said the company doesn’t have any competitors to the extent of his knowledge, at least not at the industrial scale. However, he admitted that “it’s very hard to know what the Chinese are doing in this arena.” French startup TreeFrog Therapeutics is also working on cell manufacturing, however its approach is to take cells from the skin or blood and ‘reprogramme’ them into stem cells. The company raised $75 million in September 2021.
“We’ve built this facility, which we believe is one of the world’s largest facilities, solely dedicated for production of this kind of stem cell. We’re just over 45 people here in Stockholm, and we’ve applied to the Swedish version of the FDA,” said Bernow.
“We can supply to anyone who’s serious about doing good research and making it available for patients,” he added.
In a statement, investor Fredrik Österberg said, “When it comes to investments, our focus is on companies that boast a strong business case and contribute positively to society. With the 25 years of research of Professor Le Blanc, the promising potential of MSCs for healthcare, and an exceptional team at the helm, Cellcolabs is well-positioned to revolutionise the field of stem cells and healthcare.”
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